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KMID : 0613820080180050731
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Journal of Life Science
2008 Volume.18 No. 5 p.731 ~ p.737
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Gene Targeted Mice to Study T Cell Development
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Song Ki-Duk
Kim Sang-Wook
Lee Mi-Rang
Kim Seon-Ku
Shin Teak-Soon
Kang Han-Seok
Lee Hong-Gu
Jeon Hae-Yeal
Cho Byung-Wook
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Abstract
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T cells develop in thymus, where immature progenitors undergo multi-stage developmental processes until mature CD4+ and CD8+ single positive T cells are generated and egress out to the periphery. Signals from T cell receptor are pivotal for T cell development in thymus as well as in periphery. Gene targeted mutant mice have contributed the understanding underlying mechanisms by dissecting the signaling pathways which governing these complex processes. Development of refined mutational system will be imperative to analyze the signaling pathways by taking consideration of context of ’timing and/or space’ of gene function.
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KEYWORD
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T cell development, signaling pathway, gene targeted mutant mice
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